Entry id

1_rm06rvcw

Hormone receptor positive, HER2 negative is a real spectrum disorder, there is a lot of heterogeneity and gradation of biology, and the highest risk with the patients really come in 2 flavours, one is the group of patients at risk for early recurrence. These are patients with larger tumours, higher nodal burden and generally higher grade, higher proliferation, as well as high genomic signature, 21 gene recurrence score, 70 gene signature. However, there is a second group of patients there at high risk for late recurrence. These patients also generally have breast cancers with higher tumour burden, higher tumour size, a higher nodal status, and generally can also be somewhat higher grade, somewhat more higher proliferative, but these patients remain at risk for decades. And some of those, indeed, will be indolent, but they just have a lot of high tumour burden. So, there is a spectrum of a definition of high-risk disease.