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Mounjaro ® (tirzepatide) injection
2.5 mg/5 mg/7.5 mg/10 mg/12.5 mg/15 mg
Zepbound ® (tirzepatide) injection
2.5 mg/ 5 mg/ 7.5 mg/ 10 mg/ 12.5 mg/ 15 mg
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Can a dose of Zepbound® (tirzepatide) be split into smaller doses?
Dose splitting is not recommended for Zepbound because each presentation has been designed and tested to deliver a prespecified dose.
See important safety information, including boxed warning, in the attached prescribing information.
Can a Zepbound dose be divided into multiple doses?
The Zepbound Instructions for Use do not provide instructions for administering a dose less than the full fixed dose.1-4 Please follow the approved Instructions for Use for proper storage, handling, and administration of Zepbound.1-4
Eli Lilly and Company cannot make any recommendations on splitting a tirzepatide dose to make smaller or multiple doses because this has not been studied. Each presentation has been designed and tested to deliver pre-specified dose(s) as described in the approved Instructions for Use.1-4
Lilly has not studied splitting of Zepbound multiple-dose pen (KwikPen) or multiple-dose vial into smaller doses. Therefore, there is no efficacy and safety information available on this topic.5
According to the Centers for Disease Control and Prevention (CDC), medicines designated as single-dose are for a single injection in a single patient.5
Splitting of a single-dose medicine into smaller doses may increase risks of contamination.5
Enclosed Prescribing Information
ZEPBOUND® (tirzepatide) Injection, for subcutaneous use, Lilly
References
- Zepbound single-dose pen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2026.
- Zepbound single-dose vial [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2026.
- Zepbound KwikPen [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2026.
- Zepbound multi-dose vial [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2026.
- Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: August 25, 2026