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  1. Medical Information Right
  2. Obesity Right
  3. Zepbound (tirzepatide) injection Right
  4. Can the Zepbound® (tirzepatide) vial be split into smaller doses?
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Zepbound ® (tirzepatide) injection

2.5 mg/ 5 mg/ 7.5 mg/ 10 mg/ 12.5 mg/ 15 mg

Full Prescribing Information

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

Can the Zepbound® (tirzepatide) vial be split into smaller doses?

Splitting of a tirzepatide vial into smaller doses is not recommended. The tirzepatide vial does not contain a preservative and is for single-dose use.

US_cFAQ_TZPCWM364_VIAL_DOSE_SPLITTING_CWM
US_cFAQ_TZPCWM364_VIAL_DOSE_SPLITTING_CWMen-US

See important safety information, including boxed warning, in the attached prescribing information.

Splitting of Tirzepatide Single-Dose Vial

Splitting a dose of tirzepatide from a vial into smaller doses is not recommended.

The tirzepatide vial does not contain a preservative.1 It should be injected as soon as the needle is pushed through the rubber stopper and the solution is removed from the vial.2

Throw away all opened vials after use, even if there is medicine left in the vial.2

The tirzepatide vial is for single-dose use.1

According to the Centers for Disease Control and Prevention (CDC), vials designated as single-dose are for a single injection in a single patient.3

Splitting of a single-dose vial into smaller doses may increase risks of vial contamination.3

Eli Lilly and Company has not studied splitting of tirzepatide vial into smaller doses. Therefore, there is no efficacy and safety information available on this topic.

Please refer to the approved US Prescribing Information, Medication Guide, and Instructions For Use for instructions on proper storage, handling, and administration of the tirzepatide vial. 1,2,4

Enclosed Prescribing Information

ZEPBOUND® (tirzepatide) injection, for subcutaneous use, Lilly

References

1Zepbound [package insert]. Indianapolis, IN: Eli Lilly and Company; 2024.

2Zepbound Single-Dose Vial [instructions for use]. Indianapolis, IN: Eli Lilly and Company; 2024.

3Centers for Disease Control and Prevention (CDC). Preventing Unsafe Injection Practices. March 2024. Accessed July 23, 2024. https://www.cdc.gov/injection-safety/hcp/clinical-safety/

4Zepbound [medication guide]. Indianapolis, IN: Eli Lilly and Company; 2024.

Date of Last Review: June 19, 2024

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