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Zepbound ® (tirzepatide) injection
2.5 mg/ 5 mg/ 7.5 mg/ 10 mg/ 12.5 mg/ 15 mg
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
Can ZEPBOUND™ (tirzepatide) be used in patients with gastroparesis?
Tirzepatide has not been studied in people with severe gastroparesis and is therefore not recommended in these patients.
See important safety information, including boxed warning, in the attached prescribing information.
Gastroparesis
Tirzepatide delays gastric emptying. This delay is largest after the first dose and diminishes over time.1
The use of tirzepatide has been associated with gastrointestinal adverse reactions, sometimes severe.1
In clinical trials, severe gastrointestinal adverse reactions were reported
- 1.7% of participants treated with tirzepatide 5 mg
- 2.5% of participants treated with tirzepatide 10 mg
- 3.1% of participants with tirzepatide 15 mg
- 1% of participants treated with placebo.1
Tirzepatide has not been studied in patients with severe gastrointestinal disease, including severe gastroparesis, and is therefore not recommended in these patients.1
Tirzepatide has not been studied in people with severe gastrointestinal disease and patients with significant gastric emptying abnormality, such as severe gastroparesis, because they were excluded from the SURPASS and SURMOUNT clinical trials if they had a known clinically significant gastric emptying abnormality (for example, severe diabetic gastroparesis or gastric outlet obstruction).2
Patient safety is Eli Lilly and Company’s top priority, and we actively engage in monitoring, evaluating, and reporting safety information for all our medicines.
Enclosed Prescribing Information
Reference
1Zepbound [package insert]. Indianapolis, IN: Eli Lilly and Company; 2023.
2Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: November 08, 2023