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  1. Medical Information Right
  2. Neuroscience Right
  3. Tauvid (flortaucipir F18 injection) Right
  4. How does Tauvid™ (flortaucipir F 18) work?
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Tauvid ™ (flortaucipir F18 injection)

300-3700 MBq/mL

Full Prescribing Information

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

How does Tauvid™ (flortaucipir F 18) work?

Tauvid (flortaucipir F 18) selectively binds to aggregated tau protein, with no significant binding to beta-amyloid, α-synuclein, or non-Alzheimer’s disease tau conformations.

US_cFAQ_FTP001_MOA
US_cFAQ_FTP001_MOAen-US

Flortaucipir F 18 Mechanism of Action

Flortaucipir F 18 binds to aggregated tau protein. In the brains of patients with Alzheimer's disease (AD), tau aggregates combine to form neurofibrillary tangles, one of two components required for the neuropathological diagnosis of AD.1

In vitro, flortaucipir F 18

  • binds to paired helical filament (PHF) tau purified from brain homogenates of donors with AD, and
  • has a dissociation constant (Kd) from PHFs of 0.57 nM.1

In vivo, flortaucipir F 18 is differentially retained in neocortical areas that contain aggregated tau.1

Autoradiography studies with flortaucipir F 18 demonstrated selectivity for tau relative to

  • beta-amyloid2,3
  • other synucleinopathies,3 and
  • other non-AD tauopathies.3

Enclosed Prescribing Information

Tauvid™ (Flortaucipir F 18 injection) for intravenous use, Lilly

References

The published references below are available by contacting 1-800-LillyRx (1-800-545-5979).

1Tauvid [package insert]. Indianapolis, IN: Eli Lilly and Company; 2024.

2Xia C-F, Arteaga J, Chen G, et al. [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement. 2013;9(6):666-676. https://doi.org/10.1016/j.jalz.2012.11.008

3Marquié M, Normandin MD, Vanderburg CR, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015;78(5):787-800. http://dx.doi.org/10.1002/ana.24517

Date of Last Review: October 18, 2024

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