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Tauvid ™ (flortaucipir F18 injection)
300-3700 MBq/mL
This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.
How much radiation does Tauvid™ (flortaucipir F 18) expose a patient to?
The effective radiation dose from a 370-MBq (10 mCi) dose of Tauvid (flortaucipir F 18) is 8.7 mSv. The organs with the highest radiation-absorbed doses were the upper intestinal wall, small intestines, and liver.
Radiation Dosimetry
Following intravenous administration of flortaucipir F 18, the drug was distributed throughout the body with less than
- 10% of the injected F 18 radioactivity present in the blood by 5 minutes following administration, and
- 5% present in the blood by 10 minutes after administration.1
The estimated radiation-absorbed doses for an average adult weighing 70 kg from intravenous injection of flortaucipir F 18 are shown in Estimated Radiation Absorbed Dose After a Flortaucipir F 18 Injection. The organs with the highest radiation-absorbed doses were the
Organ/Tissue |
Mean Absorbed Dose Per Unit |
Adrenal glands |
14 |
Brain |
8 |
Breasts |
7 |
Gallbladder wall |
38 |
Lower large intestine wall |
35 |
Small intestine wall |
85 |
Stomach wall |
13 |
Upper large intestine wall |
96 |
Heart wall |
30 |
Kidneys |
40 |
Liver |
57 |
Lungs |
34 |
Muscle |
9 |
Ovaries |
21 |
Pancreas |
14 |
Red bone marrow |
10 |
Osteogenic cells |
12 |
Skin |
6 |
Spleen |
10 |
Testes |
7 |
Thymus gland |
9 |
Thyroid |
7 |
Urinary bladder wall |
38 |
Uterus |
18 |
Total body |
12 |
Effective dose (µSv/MBq)a |
24 |
aAssumed radiation weighting factor, wr (formerly defined as quality factor, Q), of 1 for conversion of absorbed dose (Gray or rads) to dose equivalent (Sieverts or rem) for F 18. To obtain radiation absorbed dose in rad/mCi from above table, multiply the dose in μGy/MBq by 0.0037 (eg, 14 μGy/MBq x 0.0037 = 0.0518 rad/mCi).
Effective Dose
The effective radiation dose resulting from a 370-MBq (10-mCi) dose of flortaucipir F 18 is 8.7 mSv in an adult.1
The use of a computed tomography (CT) scan to calculate attenuation correction for reconstruction of flortaucipir F 18 images, as done in positron emission tomography (PET)/CT imaging, will result in additional radiation exposure dependent on the settings used in the CT acquisition.1,2
Enclosed Prescribing Information
References
1Tauvid [package insert]. Indianapolis, IN: Eli Lilly and Company; 2022.
2Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review: May 23, 2023