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  1. Medical Information Right
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  3. Amyvid (florbetapir F18 injection) Right
  4. How quickly is Amyvid® (florbetapir F 18) cleared from the body?
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Amyvid ® (florbetapir F18 injection)

500-1900 MBq/mL

Full Prescribing Information

This information is provided in response to your request. Resources may contain information about doses, uses, formulations and populations different from product labeling. See Prescribing Information above, if applicable.

How quickly is Amyvid® (florbetapir F 18) cleared from the body?

Amyvid (florbetapir F 18) has a half-life of 109.77 minutes. Following intravenous administration to healthy volunteers, the drug was distributed throughout the body with 2% of injected 18F present in the blood by 45 minutes after administration.

US_cFAQ_FBP002_CLEARANCE
US_cFAQ_FBP002_CLEARANCEen-US

Clearance, Metabolism, and Excretion

Florbetapir F 18 is radiolabeled with [18F] fluorine (F 18), which has a half-life of 109.77 minutes.1 

Following the intravenous administration of 370 MBq (10 mCi) of florbetapir F 18 to healthy volunteers, the drug was distributed throughout the body with less than

  • 5% of the injected 18F radioactivity present in the blood by 20 minutes following administration, and
  • 2% present in the blood by 45 minutes after administration.1

The residual F 18 in circulation during the 30- to 90-minute imaging window was principally in the form of polar F 18 metabolites.1

Whole body scanning following the intravenous injection showed

  • accumulation of radioactivity in the liver within four minutes post-injection
  • elimination of the radioactivity predominantly through the biliary/gastrointestinal tract, and
  • much lower radioactivity in the bladder.1 

Essentially all radioactivity collected in the urine was present as polar metabolites of florbetapir F 18.1

Enclosed Prescribing Information

Amyvid® (Florbetapir F 18 Injection) for intravenous use, Lilly

Reference

1Amyvid [package insert]. Indianapolis, IN: Eli Lilly and Company; 2023.

Date of Last Review: April 17, 2024

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