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Trulicity ® (dulaglutide)
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Can Trulicity® (dulaglutide) be used in patients with impaired hepatic function?
No dose adjustment is needed based on hepatic impairment.
Clinical Pharmacology Study: Impaired Hepatic Function
The pharmacokinetics of dulaglutide were evaluated in a clinical pharmacology study, where subjects with hepatic impairment had statistically significant decreases in dulaglutide exposure of up to 30 % to 33 % for mean Cmax and AUC, respectively, compared to healthy controls.1
There was a general increase in tmax of dulaglutide with increased hepatic impairment. However, no trend in dulaglutide exposure was observed relative to the degree of hepatic impairment. These effects were not considered to be clinically relevant.1
References
1Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
Date of Last Review: 23 February 2024