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Trulicity ® (dulaglutide)
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How should Trulicity® (dulaglutide) be dosed?
The approved dosing of once weekly dulaglutide for adults is 0.75 mg as monotherapy and 1.5 mg as add-on therapy with optional dose escalations to 3 mg and 4.5 mg. For paediatric patients the starting dose is 0.75 mg with a maximum of 1.5 mg.
Approved dose of once weekly dulaglutide
Approved Dulaglutide Dosage for Adults
Monotherapy
The recommended dose of dulaglutide is 0.75 mg once weekly as monotherapy.1
Add-on Therapy
The recommended dose of dulaglutide is 1.5 mg once weekly as add-on therapy.1
If needed,
- the 1.5 mg dose can be increased after at least 4 weeks to 3 mg once weekly
- the 3 mg dose can be increased after at least 4 weeks to 4.5 mg once weekly.
The maximum dose is 4.5 mg once weekly.1
Approved Dulaglutide Dosage for Pediatric Patients
The starting dose for paediatric patients 10 years and above is 0.75 mg once weekly.1
If needed, the dose can be increased to 1.5 mg once weekly after at least 4 weeks. The maximum dose is 1.5 mg once weekly.1
Do I need to adjust the Dose when using Dulaglutide as add-on with other antihyperglycemic Medication?
When Dulaglutide is added to |
Dose adjustment needed/not needed |
existing metformin and/or pioglitazone therapy... |
...the current dose of metformin and/or pioglitazone can be continued. |
existing metformin and/or SGLT2ia therapy... |
...the current dose of metformin and/or SGLT2i can be continued. |
existing therapy of a sulphonylurea or insulin... |
...a reduction in the dose of sulphonylurea or insulin may be considered to reduce the risk of hypoglycaemia. |
aSGLT2i = sodium-glucose co-transporter 2 inhibitor
The use of dulaglutide does not require blood glucose self‑monitoring. Blood glucose self-monitoring is necessary to adjust the dose of sulphonylurea or insulin, particularly when dulaglutide therapy is started and insulin is reduced. A stepwise approach to insulin dose reduction is recommended.1
References
1Trulicity [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.
Date of Last Review: 29 May 2024