Please note: A modified version of the Mounjaro KwikPen will be available on the market at the same time as the initial version. While the two versions may look slightly different, they work in the same way.1 The information provided in this document applies to both the modified and initial KwikPens.

Read the Instructions for Use before using the KwikPen. The step numbers referred to below, correspond to the same numbered steps in the Instructions for Use.2

The administration of a dose of tirzepatide includes:2

• Preparing
• Priming
• Injecting
• After the injection

The supplies needed for administration:2

• Mounjaro KwikPen
• KwikPen compatible needle
  (Needles are not included in the pack. The decision on needle gauge and length remains at the discretion of the physician or pharmacist.)
• Swab
• Gauze or cotton ball
• Sharps disposal container or household container.

To prepare the pen as described in the Instructions for Use, the user should2

• wash their hands with soap and water. (Step 1)
• pull the pen cap straight off and inspect their KwikPen, the label and the medication in the pen. (Step 2)
  • Confirm the medication name and strength.
  • Make sure the pen is NOT expired or damaged.
  • Make sure the medication has not been frozen, is colourless to slightly yellow and free of particles.
• wipe the red inner seal with a swab. (Step 3)
• select a new pen needle and remove the paper tab. (Step 4)
• attach the new needle, by pushing the capped pen needle straight onto the pen and twisting it on until it's tight. (Step 5)
• pull off the outer needle shield and keep it. Pull off the inner needle shield and discard it. (Step 6)

The KwikPen must not be used, if it looks damaged, or the medicine is expired, cloudy, or coloured. For full information please refer to the Instructions for Use.2

Please note:  The illustrations below show the modified version of the KwikPen. The plunger might look different if the patient is using the initial version.1

Step 7:2

Slowly turn the dose knob until you hear 2 clicks and the  extended line is shown in the dose window. This is the prime position. It can be corrected by turning the dose knob in either direction until the prime position lines up to the dose indicator.

Step 8:2

• Hold your pen with the needle pointing up.
• Tap the cartridge holder gently to collect air bubbles at the top.

Step 9:2

Release some medicine into the air by pushing the dose knob in until it stops, then slowly count to 5 while holding the dose knob. The icon must be shown in the dose window. Do not inject into your body.

If no medicine is seen at the tip of the needle, please refer to Step 9 in the Instructions for Use for further information.2

Step 10:2

• Choose an injection site.
  a. You or another person can inject the medicine in your thigh or stomach (abdomen) at least 5 centimetres from the belly button.
  b. Another person should give you the injection in the back of your upper arm.
• Change (rotate) your injection site each week. You may use the same area of your body but be sure to choose a different injection site in that area.

Step 11:2

To dial the dose, turn the dose knob until it stops and the "1" is seen in the dose window, as indicated by the  icon. This is equal to a full dose.

Step 12:2

Insert the needle into the skin and push the dose knob to inject the medicine.

• Push the dose knob until it stops
• Slowly count to 5 while holding the dose knob.

Check the Dose window and see "0", indicated by the icon. This is the confirmation that the full dose has been administered.2

If the user does not see the "0" in the dose window, they should insert the needle back into the skin and finish the injection. They should NOT redial a dose. For further information please refer to step 13 in the Instructions for Use.2

After injection, the user should2

• lightly press the injection site with gauze or a cotton ball if they see blood, and not rub the injection site. (Step14)
• carefully replace the outer needle shield. (Step 15)
• unscrew the needle and put it in a sharps container. and not store the pen with the needle attached. (Step 16)
• replace the pen cap and NOT store the pen without the pen cap attached. (Step 17)

How to store the used pen:2

• at room temperature up to 30°C after the injection.
• Keep away from heat.
• Keep the pen and needles out of the sight and reach of children.

How to dispose of the used pen:2

• Remove the needle in order to dispose of the pen
• Dispose of the pen as directed by the health care professional.

When to dispose of the pen2

Dispose of the pen

• 30 days after first use.
• after administration of 4 doses (1 dose per week).
• when the pen is expired or looks damaged.
• when the medication has been frozen, has particles, is cloudy, or is discoloured. Mounjaro should be colourless to slightly yellow.

The Instructions for Use state that the marks on the pen can not be used as dose indicators.2

Mounjaro KwikPen is used 1 time a week. A Medicine calendar Medicine calendar to track the injection dates can be found in the Instructions for Use.2

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.3